(1) Department of Medicinal Chemistry, School of Pharmacy, University of Mississippi, University, MS 38677-1848, USA
Abstract:
The microbial hydroxylation of 10-deoxoartemisinin was investigated with the aim of obtaining preparative yields of hydroxy derivatives. During 14 d at 28°C and pH 6.5 Aspergillus niger transformed 10-deoxoartemisinin (500 mg l–1) to 15-hydroxy-10-deoxoartemisinin (26%) and 7-hydroxy-10-deoxoartemisinin (69%).