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Hydroxylation of 10-deoxoartemisinin to 15-hydroxy-10-deoxoartemisinin by Aspergillus niger |
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| Authors: | Igor A Parshikov Bruhaspathy Miriyala Mitchell A Avery John S Williamson |
| Institution: | (1) Department of Medicinal Chemistry, School of Pharmacy, University of Mississippi, University, MS 38677-1848, USA |
| Abstract: | The microbial hydroxylation of 10-deoxoartemisinin was investigated with the aim of obtaining preparative yields of hydroxy derivatives. During 14 d at 28 °C and pH 6.5 Aspergillus niger transformed 10-deoxoartemisinin (500 mg l–1) to 15-hydroxy-10-deoxoartemisinin (26%) and 7 -hydroxy-10-deoxoartemisinin (69%). |
| Keywords: | antimalarial drugs artemisinin Aspergillus niger hydroxylation |
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