Effects of recombinant human PLD2 on proliferation and apoptosis of HL-60 cells |
| |
Authors: | Zhu Ling Wang Ya-Xiong Yu Chuan-Xing |
| |
Affiliation: | Immunology Department and Center of Neuroscience, Fujian Medical University, No. 88 Jiaotong Road, Fuzhou, Fujian 350004, China. zhling62@pub6.fz.fj.cn |
| |
Abstract: | In the present study, we investigated the role of recombinant human phospholipase D2 (rhPLD2) on proliferation and apoptosis in human leukemia HL-60 cells which induced by camptothecin. Our research demonstrated that various concentrations of rhPLD2 inhibit the growth of HL-60 cells in a dose-dependent manner, and rhPLD2 plus camptothecin can produce a synergistic effect on growth inhibition of HL-60 cells in vitro. So, we conclude that rhPLD2 alone cannot induce apoptosis in HL-60 cells, but it can potentiate the apoptosis of HL-60 cells induced by camptothecin. Similarly, we show that both rhPLD2 and standard PLD were able to enhance camptothecin-induced apoptosis of HL-60 cells. |
| |
Keywords: | rhPLD2 Camptothecin HL‐60 cells Apoptosis Cell cycle |
本文献已被 PubMed 等数据库收录! |
|