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Statistical implications of pooling RNA samples for microarray experiments
Authors:Email author" target="_blank">Xuejun?PengEmail author  Constance?L?Wood  Eric?M?Blalock  Kuey?Chu?Chen  Philip?W?Landfield  Arnold?J?Stromberg
Institution:(1) Department of Statistics, University of Kentucky, Lexington, KY 40506, USA;(2) Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, KY 40536, USA
Abstract:

Background  

Microarray technology has become a very important tool for studying gene expression profiles under various conditions. Biologists often pool RNA samples extracted from different subjects onto a single microarray chip to help defray the cost of microarray experiments as well as to correct for the technical difficulty in getting sufficient RNA from a single subject. However, the statistical, technical and financial implications of pooling have not been explicitly investigated.
Keywords:
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