(1) Department of Statistics, University of Kentucky, Lexington, KY 40506, USA;(2) Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, KY 40536, USA
Abstract:
Background
Microarray technology has become a very important tool for studying gene expression profiles under various conditions. Biologists
often pool RNA samples extracted from different subjects onto a single microarray chip to help defray the cost of microarray
experiments as well as to correct for the technical difficulty in getting sufficient RNA from a single subject. However, the
statistical, technical and financial implications of pooling have not been explicitly investigated.