Down-regulation of sfrp1 in a mammary epithelial cell line promotes the development of a cd44high/cd24low population which is invasive and resistant to anoikis |
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| Authors: | Kelly J Gauger Jeremy M Hugh Melissa A Troester Sallie Smith Schneider |
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| Institution: | (1) Pioneer Valley Life Sciences Institute, Baystate Medical Center, Springfield, MA 01199, USA;(2) Biology Department, University of Massachusetts, Amherst, MA 01003, USA;(3) Department of Epidemiology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;(4) Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01003, USA |
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| Abstract: | Background The Wnt family of secreted proteins is implicated in the regulation of cell fate during development, as well as in cell proliferation,
morphology, and migration. Aberrant activation of the Wnt/β-catenin signaling pathway leads to the development of several
human cancers, including breast cancer. Secreted frizzled-related protein 1 (SFRP1) antagonizes this pathway by competing
with the Frizzled receptor for Wnt ligands resulting in an attenuation of the signal transduction cascade. Loss of SFRP1 expression
is observed in breast cancer, along with several other cancers, and is associated with poor patient prognosis. However, it
is not clear whether the loss of SFRP1 expression predisposes the mammary gland to tumorigenesis. |
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