| 头孢菌素C生物合成调控研究进展北大核心CSCD |
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| 引用本文： | 刘佳佳,刘钢. 头孢菌素C生物合成调控研究进展北大核心CSCD[J]. 微生物学报, 2016, 56(3): 461-470 |
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| 作者姓名： | 刘佳佳 刘钢 |
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| 作者单位： | 中国科学院微生物研究所, 真菌学国家重点实验室, 北京 100101,中国科学院微生物研究所, 真菌学国家重点实验室, 北京 100101 |
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| 基金项目： | 国家自然科学基金(31470177) |
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| 摘 要： | 头孢菌素C由丝状真菌顶头孢霉产生,属于β-内酰胺类抗生素。其经改造后的7-氨基头孢烷酸是头孢类抗生素的重要中间体。头孢类抗生素在国内外抗生素市场中占有巨大的份额,是临床上的主要抗感染药物。随着分子生物学的发展,头孢菌素C的生物合成途径已基本阐明。为提高头孢菌素C的产量和降低生产成本,越来越多的研究者开始关注其较为精细、复杂的调控机制。本文重点对头孢菌素C生物合成及其调控机制的最新进展进行了简述,希望为今后头孢菌素C生产菌株的菌种改造和传统产业的升级换代提供一定的借鉴。
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| 关 键 词： | 顶头孢霉 头孢菌素C 生物合成 调控机制 |
| 收稿时间： | 2015-11-09 |
| 修稿时间： | 2015-12-28 |
Advances in the regulation of cephalosporin C biosynthesis-A review |
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| Jiajia Liu and Gang Liu. Advances in the regulation of cephalosporin C biosynthesis-A review[J]. Acta microbiologica Sinica, 2016, 56(3): 461-470 |
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| Authors: | Jiajia Liu and Gang Liu |
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| Affiliation: | State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China and State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China |
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| Abstract: | The beta-lactam antibiotic cephalosporin C is produced industrially by Acremonium chrysogenum. Its derivative 7-aminocephalosporanic acid (7-ACA) is the intermediate of most chemical modification cephalosporins that are the most frequently used antibiotics for the therapy of infectious diseases. Due to its importance, the biosynthetic pathway of cephalosporin C has been elucidated in Acremonium chrysogenum. To improve the yield of cephalosporin C and reduce the cost of production, recent studies have been focused on the sophisticated regulation of cephalosporin C biosynthesis. In this review, recent advances in cephalosporin C biosynthesis and regulation are summarized. |
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| Keywords: | Acremonium chrysogenum cephalosporin C biosynthesis regulation |
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