| 羊毛硫肽类化合物(Lanthipeptide)生物合成新进展 |
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| 引用本文： | 莫天录,薛林贵,张琪. 羊毛硫肽类化合物(Lanthipeptide)生物合成新进展[J]. 微生物学报, 2016, 56(3): 373-382 |
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| 作者姓名： | 莫天录 薛林贵 张琪 |
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| 作者单位： | 兰州交通大学化学与生物工程学院, 甘肃 兰州 730070;复旦大学化学系, 上海 200433,兰州交通大学化学与生物工程学院, 甘肃 兰州 730070,复旦大学化学系, 上海 200433 |
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| 基金项目： | 国家自然科学基金(KRH1615548) |
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| 摘 要： | 羊毛硫肽化合物(Lanthipeptides)是由核糖体合成并经过翻译后修饰得到的一大类肽类天然产物。这类化合物广泛的产生于不同种类的细菌,具有丰富的结构和生物活性多样性,为活性药物研究和开发提供重要的来源。本文综述了近几年来羊毛硫肽化合物生物合成进展,从其合成酶结构,进化机制,区域和立体选择性控制等方面进行了简要的讨论,展示了羊毛硫肽类化合物生物合成中特殊而迷人的酶学机制。
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| 关 键 词： | 羊毛硫肽 核糖体肽天然产物 底物控制 抗菌活性 立体选择性 |
| 收稿时间： | 2015-09-16 |
| 修稿时间： | 2015-11-25 |
Recent advances in lanthipeptide biosynthesis-A review |
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| Tianlu Mo,Lingui Xue and Qi Zhang. Recent advances in lanthipeptide biosynthesis-A review[J]. Acta microbiologica Sinica, 2016, 56(3): 373-382 |
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| Authors: | Tianlu Mo Lingui Xue Qi Zhang |
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| Affiliation: | School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou 730070, Gansu Province, China;Department of Chemistry, Fudan University, Shanghai 200433, China,School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou 730070, Gansu Province, China and Department of Chemistry, Fudan University, Shanghai 200433, China |
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| Abstract: | Lanthipeptides are a growing class of ribosomally synthesized and posttranslationally modified peptide (RiPP) natural products. These compounds are widely distributed among taxonomically distant species, and their structures and biological activities are diverse, providing an important source for drug research and developement. In this review, we summarized the recent advances in the understanding of structure, classification, evolution and substrate-controlled biosynthetic mechanism of lanthipeptide, attempting to highlight the intriguing chemistry and enzymology in the biosynthesis of this growing family of natural products. |
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| Keywords: | lanthipeptide RiPP substrate-controlled antibacterial activity stereoselectivity |
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