Lead compounds discovered from libraries: part 2 |
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Authors: | Golebiowski Adam Klopfenstein Sean R Portlock David E |
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Institution: | Procter & Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040-8006, USA. golebiowski.a@pg.com |
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Abstract: | Many lead compounds with the potential to progress to viable drug candidates have been identified from libraries during the past two years. There are two key strategies most often employed to find leads from libraries: first, high-throughput biological screening of corporate compound collections; and second, synthesis and screening of project-directed libraries (i.e. target-based libraries). Numerous success stories, including the discovery of several clinical candidates, testify to the utility of chemical library collections as proven sources of new leads for drug development. |
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