Regulation of the production of murine IgG2a by an H-2-linked gene and other unlinked genes |
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Authors: | Andrew P Dowsett Leonore A Herzenberg Leonard A Herzenberg |
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Institution: | (1) Department of Genetics, Stanford University School of Medicine, 94305 Stanford, California;(2) Present address: Department of Genetics, The Rockefeller University, 1230 York Avenue, 10021 New York, New York |
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Abstract: | Alleles of at least two loci (rig-1 and Rig-2) regulate the levels of serum immunoglobulin of the Igh-1b class and allotype in BALB/c Igb (BAB/14) and (BALB/c × BAB/14)F1 mice. The combined effect of the BALB/c alleles at these two loci is to lower Igh-1b levels significantly below those observed in other strains and below their own levels of Igh-1a in allotype heterozygous mice. The rig-1 locus is closely linked to or within the H-2 complex. Two alleles have been defined: rig-1
d and rig-1
b in H-2
d and H-2
b haplotypes, respectively. Homozygous rig-1
d d animals heterozygous for the BALB/c Rig-2 allele(s) have very low levels of Igh-1b. The designation of Rig-2 is provisional since it has not been mapped or defined as a single locus. |
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