| 绝缘子调控基因的表达 |
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| 引用本文： | 王海,张倩,方向东.绝缘子调控基因的表达[J].中国生物化学与分子生物学报,2011,27(6):493-498. |
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| 作者姓名： | 王海 张倩 方向东 |
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| 作者单位： | 中国科学院北京基因组研究所基因组科学及信息重点实验室;中国科学院研究生院; |
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| 基金项目： | 中国科学院知识创新工程“百人计划”和青年人才领域前沿项目资助~~ |
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| 摘 要： | 绝缘子在调控真核基因时空特异表达的过程中起着至关重要的作用.它的主要功能是增强子阻断和异染色质屏障.已经有竞争、阻断和成环等模型描述其增强子阻断功能；而它的异染色质屏障功能主要是通过影响染色质组蛋白的翻译后修饰来实现.已经确定的绝缘子包括果蝇基因组中的染色质特化结构(specialized chromatin structures, scs)和scs、gypsy、鸡珠蛋白β基因座上游的DNaseⅠ高敏感位点cHS4以及小鼠或人Igf2/H19基因座上的印记控制区(imprinting control region, ICR)和DNA甲基化区域(DNA methylated regions, DMR)元件等.许多转录因子参与绝缘子的基因调控作用，例如脊椎动物中的CCCTC结合因子(CCCTC binding factor，CTCF).利用基因组学和生物信息学等方法，还可以在基因组中发现新的绝缘子元件.
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| 关 键 词： | 绝缘子 异染色质 转录调控 CCCTC结合因子 |
| 收稿时间： | 2010-12-21 |
Role of Insulators in Gene Regulation |
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| WANG Hai,ZHANG Qian,FANG Xiang-DongKey Laboratory of Genome Science , Information,Beijing Institute of Genomics,Chinese Academy of Sciences,Beijing ,China,Graduate University of Chinese Academy of Sciences,Beijing ,China.Role of Insulators in Gene Regulation[J].Chinese Journal of Biochemistry and Molecular Biology,2011,27(6):493-498. |
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| Authors: | WANG Hai ZHANG Qian FANG Xiang-DongKey Laboratory of Genome Science Information Beijing Institute of Genomics Chinese Academy of Sciences Beijing China Graduate University of Chinese Academy of Sciences Beijing China |
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| Institution: | WANG Hai1),2),ZHANG Qian1),FANG Xiang-Dong1)(1)Key Laboratory of Genome Science and Information,Beijing Institute of Genomics,Chinese Academy of Sciences,Beijing 100029,China,2)Graduate University of Chinese Academy of Sciences,Beijing 100049,China) |
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| Abstract: | Insulators play an important role in regulating the proper temporal and spatial expression of eukaryotic genes.Insulators are classically defined by their ability to perform two key functions.First,they can block enhancer function.Recently,the decoy,barrier and looping models have been proposed to account for the enhancer blocking mechanisms of insulators.Second,insulators can serve as a barrier to heterochromatin.This barrier function is thought to involve the recruitment of histone-modifying enzymes.Many ... |
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