| 组蛋白H3K27去甲基化酶与肿瘤发生 |
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| 引用本文： | 郭晓强,陆菁潇,桂耀庭,段相林,蔡志明. 组蛋白H3K27去甲基化酶与肿瘤发生[J]. 中国生物化学与分子生物学报, 2011, 27(8): 706-711 |
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| 作者姓名： | 郭晓强 陆菁潇 桂耀庭 段相林 蔡志明 |
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| 作者单位： | 北京大学深圳医院男性生殖与遗传广东省重点实验室;河北师范大学生命科学学院铁代谢分子生物学研究室;解放军白求恩军医学院生化教研室;深圳市第二人民医院; |
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| 基金项目： | 深圳市重点实验室提升计划(No.CXB201005250016A); 国家自然科学基金(No.30870265); 广东省男性生殖与遗传重点实验室开放基金(No.2010002)~~ |
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| 摘 要： | 组蛋白甲基化是一种重要的表观遗传学修饰，在基因表达调节方面发挥着重要的作用.组蛋白H3赖氨酸27三甲基化（H3K27me3）是一种抑制性组蛋白标记，可被去甲基化酶UTX和JMJD3催化而移去甲基.UTX和JMJD3通过激活HOX基因而参与细胞分化和多能细胞抑制过程.在多种肿瘤中检测到UTX和JMJD3突变或表达下降，同时多种基因启动子区H3K27me3含量增多.UTX和JMJD3均被看作肿瘤抑制基因，其中UTX调节了RB依赖的细胞命运控制，而JMJD3通过激活INK4b-ARF-INK4a位点而参与了癌基因诱导的衰老.组蛋白H3K27去甲基化酶与肿瘤发生的研究使我们对癌症发展过程有了更好的理解，同时也为癌症诊断和治疗提供了新靶点.
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| 关 键 词： | 组蛋白 H3K27去甲基化酶 肿瘤发生 表观遗传学 |
| 收稿时间： | 2011-03-07 |
Histone H3K27 Demethylases and Tumorigenesis |
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| GUO Xiao-Qiang),),),LU Jing-Xiao),GUI Yao-Ting),DUAN Xiang-Lin),CAI Zhi-Ming),) Guangdong Key Laboratory of Male Reproductive Medicine , Genetics,Peking University Shenzhen Hospital,Shenzhen Guangdong,China,)Laboratory of Iron Metabolism , Molecular Biology,School of Life Science,Hebei Normal University,Shijiazhuang ,). Histone H3K27 Demethylases and Tumorigenesis[J]. Chinese Journal of Biochemistry and Molecular Biology, 2011, 27(8): 706-711 |
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| Authors: | GUO Xiao-Qiang) ) ) LU Jing-Xiao) GUI Yao-Ting) DUAN Xiang-Lin) CAI Zhi-Ming) ) Guangdong Key Laboratory of Male Reproductive Medicine Genetics Peking University Shenzhen Hospital Shenzhen Guangdong China )Laboratory of Iron Metabolism Molecular Biology School of Life Science Hebei Normal University Shijiazhuang ) |
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| Affiliation: | GUO Xiao-Qiang1),2),3),LU Jing-Xiao1),GUI Yao-Ting1),DUAN Xiang-Lin2)*,CAI Zhi-Ming1),4)*(1) Guangdong Key Laboratory of Male Reproductive Medicine and Genetics,Peking University Shenzhen Hospital,Shenzhen 518036 Guangdong,China,2)Laboratory of Iron Metabolism and Molecular Biology,School of Life Science,Hebei Normal University,Shijiazhuang 050016,3)Department of Biochemistry,Bethune Military Medical College,Shijiazhuang 050081,4) The Second People's Hospital of Shenzhen,Shenzhen 518036,Guangd... |
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| Abstract: | Histone methylation is an important epigenetic modification and plays vital roles in the regulation of gene expression.Histone 3 lysine 27 tri-methylation(H3K27me3) is a repressive histone mark and can be catalyzed the removal of methyl group by H3K27 demethylases UTX and JMJD3.Both UTX and JMJD3 are involved for cell differentiation and multipotent cell inhibition through catalysing the demethylation of H3K27me3 on the HOX genes locus and HOX activation.It was discovered that UTX and JMJD3 were mutated or ... |
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| Keywords: | histone H3K27 demethylase tumorigenesis epigenetics |
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