硫酸类肝素中的N－非取代葡糖胺残基的功能、结构与生物合成

硫酸类肝素在人类的某些重大疾病如癌症、艾滋病、老年痴呆症中扮演着一些 重要的角色，因而是现今糖类化合物中研究的热门焦点之一.近年的研究表明, 硫酸 类肝素中所含的微量结构,即N－非取代葡萄糖胺残基有着重要的生物学与病理生理学 作用.它与病毒的侵入、脑组织损伤、蛋白聚糖的体内循环等作用密切相关.对硫酸类 肝素中N－非取代葡糖胺残基的结构、功能及其生物体内合成途径的研究将有助于揭 示某些疾病的发病机制，为改善诊断方法和发展药物提供可能.本文综述近10多年来 国内外在该领域的最新研究进展.

Function,Structure and Biosynthesis of N-unsubstituted Glucosamine in Heparan Sulfate

Heparan sulfate has become a very popular research subject in the glycobiology field because it plays a number of important roles in cancer,AIDS and Alzheimer's disease.Recently,it is clear that the rare N-unsubstituted glucosamine residues in heparan sulfate plays important biological and pathophysiological roles in virus invasion,brain tissue lesions and proteoglycan recycling.Studies on GlcNH+3 residues in heparan sulfate will reveal the pathogenesis of some diseases,and offer improved diagnostic opportu...