Antigen-Induced leukotriene relaese from rat lung |
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Authors: | G Brunet S Charleson AW Ford-Hutchinson |
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Institution: | Merck Frosst Canada Inc. P.O. Box 1005, Pointe Claire-Dorval, Québec, Canada H9R 4P8 |
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Abstract: | Chopped lung from inbred hyperreactive rats was challenged with antigen following active on passive sensitization and supernatants were assayed for the presence of leukotrienes (LTs) by radioimmunoassay. Dose-related increases in the release of LTC4- and LTB4-immunoreactive material were obtained with significantly more material being released following passive sensitization. Chromatographic analysis indicated the presence of LTB4, LTC4 and LTE4. When LT release inbredred rats was compared to Sprague-Dawley or Fischer rats, the amounts released were as follows: Inbred > Sprague-Dawley > Fischer. It was concluded that the release of LTs in the three strains correlated with the degree of non-specific bronchial hyperreactivity. |
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