Hepatic zonation of carbon and nitrogen fluxes derived from glutamine and ammonia transformations |
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| Authors: | Jurandir F Comar Fumie Suzuki-Kemmelmeier Jorgete Constantin and Adelar Bracht |
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| Institution: | (1) Laboratory of Liver Metabolism, Biochemistry Department, University of Maring?, Maring?, Brazil |
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| Abstract: | Background Glutaminase predominates in periportal hepatocytes and it has been proposed that it determines the glutamine-derived nitrogen
flow through the urea cycle. Glutamine-derived urea production should, thus, be considerably faster in periportal hepatocytes.
This postulate, based on indirect observations, has not yet been unequivocally demonstrated, making a direct investigation
of ureogenesis from glutamine highly desirable. |
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