Quel avenir pour l’imagerie TEMP du petit animal ? |
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| Institution: | 1. Service de biophysique et médecine nucléaire, CHU de Hautepierre, Strasbourg 67098, France;2. ENST GET/TSI, 46, rue Barrault, Paris 75634, France;1. Service hospitalo-universitaire de santé mentale et de thérapeutique, centre hospitalier Sainte-Anne, université Paris-Descartes, 1, rue Cabanis, 75014 Paris, France;2. Inserm UMR 894, centre de psychiatrie et neurosciences, université Paris-Descartes, Sorbonne, Paris Cité, Paris, France;3. Service du Dr. Zagury, clinique du Bois Bondy, 93G11 EPS Ville Evrard, France;1. Service hospitalo-universitaire de santé mentale et de thérapeutique, hôpital Sainte-Anne, université Paris Descartes, centre hospitalier Sainte-Anne, 1, rue Cabanis, 75014 Paris, France;2. Inserm UMR 894, centre de psychiatrie et neurosciences, université Paris Descartes, Sorbonne Paris Cité, 75014 Paris, France;3. Clinique du Bois Bondy, 93G11 EPS Ville Evrard, 93140 Bondy, France;1. Science de l’Homme et de la Société, laboratoire Psy-NCA EA 4700, université de Rouen, rue Lavoisier, 76821 Mont-Saint-Aignan, France;2. Université de Rouen, 1, rue Thomas-Becket, 76821 Mont-Saint-Aignan, France;1. University Hospital, Nantes, France;2. Institut de Cancérologie de l''Ouest Cancer Center, Saint-Herblain, France;3. Haematology Department, Hospital, La Roche sur Yon, France;4. Institut Bergonié, Cancer Centre, and University of Bordeaux, Bordeaux, France;5. University Hospital, Clermont-Ferrand, France;6. Jean Minjoz Hospital, Besançon, France;7. Centre Hospitalier Bretagne-Atlantique, Vannes, France;8. Catherine de Sienne Center, Nantes, France;9. University Hospital Haut-Leveque, Bordeaux, France;10. Hematology and Cell Therapy Department, Clinical Investigation Center INSERM U1415, GICC UMR CNRS 7292, University Hospital, Tours, France;11. University Hospital, Angers, France;12. University Hospital, Grenoble, France;13. University Hospital, Brest, France;14. Hôpital du Scorff, Lorient, France;15. Cochin Hospital, Assistance Publique—Hôpitaux de Paris, Paris, France;p. Eugène Marquis Cancer Center, Rennes, France;q. Groupement d''Intêret Publique Arronax, Arronax, Saint-Herblain, France;r. Clinical Research, Immunomedics, Morris Plains, NJ, USA;s. University Hospital, Rennes, France;1. Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA;2. National Institute on Drug Dependence, Peking University, Beijing 100191, China;1. Nuclear Medicine and Endocrine Oncology, Gustave Roussy, Paris, France;2. Biostatistics and Epidemiology, Gustave Roussy, Paris, France;3. University Paris-Saclay, Paris, France;4. Endocrinology, CHU Bordeaux, Bordeaux, France;5. Nuclear Medicine, Institut Universitaire du Cancer Toulouse Oncopole, Toulouse, France;6. Nuclear Medicine, Centre François Baclesse, Caen, France;7. Nuclear Medicine, Centre René Gauducheau, Nantes, France;8. Nuclear Medicine, Institut Bergonié, Bordeaux, France;9. Endocrinology, Hôpital Pitié-Salpétrière, Paris, France;10. Nuclear Medicine, Institut Jean Godinot, Reims, France;11. Nuclear Medicine, Centre Becquerel, Rouen, France;12. Nuclear Medicine, ICO Paul Papin, Angers, France;13. Nuclear Medicine, Centre Lacassagne, Nice, France;14. Nuclear Medicine, CHU Lyon, France;15. Nuclear Medicine, Hôpital Saint-Louis, Paris, France;p. Nuclear Medicine, Centre Jean Perrin, Clermont-Ferrand, France |
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| Abstract: | Functional and anatomical small animal imaging represents one of the most promising tool in preclinical research capable of in vivo quantitative analysis of induced abnormalities in animal models and evaluation of metabolic, functional, and morphological consequences of genomic alterations in order to establish new therapeutic and diagnostic drugs. Among all the methods, SPECT imaging has recently benefited from numerous technological developments leading to submillimeter spatial resolutions with increasing detection sensitivity. Moreover, availability and sensitivity of single photon radiotracers are serious advantages of the method, which should play an important role in pre clinical imaging. The aim of this article is to present and discuss these small animal SPECT imaging advances. |
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