Genetics strongly determines the wall thickness of the left and right carotid arteries |
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Authors: | F Zannad S Visvikis R Gueguen C Sass O Chapet B Herbeth G Siest |
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Institution: | (1) Centre d’Investigation Clinique-INSERM-CHU de Nancy, CO N°34, F-54035 Nancy Cedex, France Tel.: +33 3 83 65 66 25, Fax +33 3 83 65 66 19, FR;(2) Centre de Médecine Préventive, Vandoeuvre lès Nancy, France, FR |
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Abstract: | In 76 supposedly healthy families, we investigated the familial resemblance of left and right carotid intima-media thickness
(IMT) measured by B-mode ultrasonography and the impact of the common apolipoprotein E (apo E) polymorphism and the insertion/deletion
polymorphism of the angiotensin-converting enzyme (ACE). Genetic factors accounted for about 30% of IMT variation. The insertion/deletion
ACE polymorphism did not influence carotid IMT, whereas apoE polymorphism explained about 1.5% of only right carotid IMT variability
independently of cholesterol levels. The apo ɛ2 and apo ɛ4 alleles were associated with lower right carotid IMT than was the
apo ɛ3 allele. We conclude that genetic factors strongly contribute to IMT variability in healthy people and that the apo
E polymorphism may be one of these factors.
Received: 10 November 1997 / Accepted: 20 Match 1998 |
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