| 5-氟尿嘧啶前体药物研究进展 |
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| 引用本文： | 孙维彤,陈倩倩,张娜,于泳,李莉,于莲,杨春荣,苏瑾,胡艳秋.5-氟尿嘧啶前体药物研究进展[J].生命的化学,2014(2):269-274. |
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| 作者姓名： | 孙维彤 陈倩倩 张娜 于泳 李莉 于莲 杨春荣 苏瑾 胡艳秋 |
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| 作者单位： | [1]佳木斯大学药学院,黑龙江省生物药制剂重点实验室,佳木斯154007 [2]山东大学药学院,济南250012 [3]佳木斯市质量技术监督检验检测中心,佳木斯154002 [4]佳木斯大学附属第二医院,佳木斯154002 |
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| 基金项目： | 黑龙江省教育厅科学技术研究项目（12531667）. |
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| 摘 要： | 5-氟尿嘧啶(5-fluorouracil,5-FU)是目前临床广泛应用的抗癌药物之一,抗瘤谱广,但其毒副作用大,治疗剂量与中毒剂量接近,且半衰期短,口服吸收不稳定,严重限制了其临床应用。5-氟尿嘧啶前体药物能够增强抗肿瘤活性和靶向性,同时降低5-氟尿嘧啶的毒副作用。文章综述了近年来5-氟尿嘧啶前药及其靶向抗肿瘤活性研究进展。
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| 关 键 词： | 5-氟尿嘧啶 抗肿瘤 前药 靶向性 |
Advances on prodrugs of 5-Fluorouracil |
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| SUN Weitong,CHEN Qianqian,ZHANG Na,YU Yong,LI Li,YU Lian,YANG Chunrong,SU Jin,Hu Yanqiu.Advances on prodrugs of 5-Fluorouracil[J].Chemistry of Life,2014(2):269-274. |
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| Authors: | SUN Weitong CHEN Qianqian ZHANG Na YU Yong LI Li YU Lian YANG Chunrong SU Jin Hu Yanqiu |
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| Institution: | 1Pharmaceutical College of Jiamusi University, Key Laboratory of Biological Medicine Preparations of Heilongjiang Province, Jiamusi 154007, China;2School of Pharmaceutical sciences, Shandong University, Ji＇nan 250012, China; 3jiamusi Quality and Technical Supervision and Inspection Center, Jiamusi 154002, China; 4The Second Affiliated Hospital of Jiamusi University, Jiamusi 154002, China) |
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| Abstract: | 5-Fluorouracil （5-FU） is one of widely used anticancer drugs clinically at present. However, the clinical utility of 5-FU might be limited due to its serious adverse effects, a therapeutic does close toxic dose, a short half-life and an instable oral absorption. The prodrugs of 5-FU can enhance its anti-tumor activity and improve the targeting ability, also reduces its adverse effects. The recent advances on prodrugs of 5-FU and their targeting antitumor activities have reviewed in this paper. |
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| Keywords: | 5-Fluorouracil antitumor prodrugs targeting ability |
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