| 登革病毒疫苗研究现状与展望 |
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| 引用本文： | 李敏,金侠.登革病毒疫苗研究现状与展望[J].生命的化学,2014(1):29-38. |
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| 作者姓名： | 李敏 金侠 |
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| 作者单位： | 中国科学院上海巴斯德研究所,病毒疾病与疫苗转化研究组,疫苗中心,上海200031 |
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| 基金项目： | 国家自然科学基金项目（81071359;81128008）;上海巴斯德健康研究基金会项目（Y359P41505） |
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| 摘 要： | 登革病毒是属于黄病毒科的小型包膜病毒,在热带和亚热带地区通过蚊媒传播。其感染可引起临床症状轻微的登革热,甚至危及生命的登革出血热和登革休克综合征。登革病毒包含4种血清型,有效的登革病毒疫苗需对4种血清型的登革病毒均具有抗病毒保护作用。目前,尚未有针对登革病毒的特效药和成熟的疫苗产品。各类登革病毒疫苗均在研发中,其中一些已进入临床试验阶段。本文就登革病毒疫苗研究进展作一综述并对未来发展进行展望。
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| 关 键 词： | 登革病毒 免疫 疫苗 |
Current progress and future perspectives of dengue vaccine development |
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| LI Min,JIN Xia.Current progress and future perspectives of dengue vaccine development[J].Chemistry of Life,2014(1):29-38. |
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| Authors: | LI Min JIN Xia |
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| Institution: | (Viral Disease and Vaccine Translational Research Unit, Vaccine Center, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China) |
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| Abstract: | Dengue virus is a small, enveloped virus that belongs to the Flaviviridae family. Transmitted by mosquitoes in tropical and subtropical regions, dengue virus can cause dengue fever and life-threatening dengue hemorrhagic fever and dengue shock syndrome. Currently, no licensed vaccines or specific antiviral drugs are available. Dengue viruses consist of four serotypes. Effective dengue vaccines will need to confer protection against each of the four dengue serotypes. A variety of vaccine candidates are under development, some of which are in clinical testing. Here, the current progress and future perspectives of dengue vaccine development are discussed. |
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| Keywords: | dengue virus immunity vaccine |
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