| G-四链体核酸的生物学功能 |
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| 引用本文： | 常天俊,李刚,李卫国. G-四链体核酸的生物学功能[J]. 生命的化学, 2014, 0(3): 385-391 |
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| 作者姓名： | 常天俊 李刚 李卫国 |
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| 作者单位： | 河南理工大学资源环境学院,焦作454000 |
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| 基金项目： | 北京分子科学国家实验室开放课题基金（2012年度）;河南省教育厅科学技术研究重点项目（13A180328） |
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| 摘 要： | G-四链体是由富含鸟嘌呤的DNA或RNA折叠形成的高级结构。可形成G-四链体的序列在人基因组中广泛分布,涉及DNA复制、端粒维持、基因表达与调控以及遗传不稳定性等过程。研究发现有些化学合成的G-四链体序列也具有生物活性,如核仁素的核酸适体AS1411具有抑制恶性肿瘤增殖活性。G-四链体的生物学功能研究对于恶性疾病的发病机理和靶向治疗,以及设计开发核酸类抗癌药物有重要意义。
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| 关 键 词： | G-四链体 功能核酸 核酸适体 分子识别 |
The biological functions of G-quadruplex nucleic acids |
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| CHANG Tianjun,LI Gang,LI Weiguo. The biological functions of G-quadruplex nucleic acids[J]. Chemistry of Life, 2014, 0(3): 385-391 |
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| Authors: | CHANG Tianjun LI Gang LI Weiguo |
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| Affiliation: | (School of Resources and Environment Engineering, He＇nan Polytechnic University, Jiaozuo 454000, China) |
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| Abstract: | G-quadruplexes （G4s） are four-stranded DNA or RNA secondary structures formed in special G-riching sequences. Putative G-quadruplex-forming sequences are highly prevalent in human genome, involved in DNA replication, telomere maintenance, gene expression and regulation, and genetic instability. Synthetic G-quadruplexes also have important biological functions, e.g., AS1411 is reported as an anti-nucleolin aptamer and has cancer-selective antiproliferative activity. Therefore, studying the biological functions of G-quadruplexes is very important for the pathogenesis and targeted therapy of malignancies, and for the design and development of nucleic acids anti-cancer drugs. |
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| Keywords: | G-quadruplex functional nucleic acid aptamer molecular recognition |
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