| P-糖蛋白的细胞内转运及表达调控 |
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| 引用本文： | 汤燕,高巧慧,吴臻,李发荣.P-糖蛋白的细胞内转运及表达调控[J].生命的化学,2014(1):93-97. |
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| 作者姓名： | 汤燕 高巧慧 吴臻 李发荣 |
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| 作者单位： | 药用资源与天然药物化学教育部重点实验室,西北濒危药材资源开发国家工程实验室,陕西师范大学生命科学学院,西安710062 |
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| 基金项目： | 陕西省自然科学基金项目（2012JM4010）;中央高校基本科研业务费专项基金项目（GK261001001） |
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| 摘 要： | 肿瘤多药耐药(multidrug resistance,MDR)的发生多与P-糖蛋白(P-glycoprotein,P-gp)过度表达相关。作为一种糖蛋白,P-糖蛋白在内质网中合成、折叠,然后转运到高尔基体进行加工、修饰,最终定位于细胞膜,且只有定位于细胞膜的P-糖蛋白才与肿瘤多药耐药的产生相关。P-糖蛋白的表达与多种信号通路如MAPK、Wnt/β-catenin、PKC、NF-κB有关。研究证实,还有多种miRNA与肿瘤多药耐药的发生相关。本文综述了P-糖蛋白的细胞内转运过程及P-糖蛋白表达相关信号通路的研究进展,为以P-糖蛋白为靶标的肿瘤多药耐药逆转剂提供新的研究策略。
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| 关 键 词： | P-糖蛋白 肿瘤多药耐药 细胞内转运 信号通路 miRNA |
Intracellular transport and express regulation of P-glycoprotein |
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| TANG Yan,GAO Qiaohui,WU Zhen,LI Farong.Intracellular transport and express regulation of P-glycoprotein[J].Chemistry of Life,2014(1):93-97. |
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| Authors: | TANG Yan GAO Qiaohui WU Zhen LI Farong |
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| Institution: | (Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, Ministry of Education, National Engineering Laboratory for Resource Developing of Endangered Chinese Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi＇an 710062, China) |
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| Abstract: | Multidrug resistance （MDR） is related to over expression of P-gp. As a kind of glycoprotein, P-gp synthetize and folding in endoplasmic reticulum, then transfer to Golgi for fabrication and modification, finally located in cell membrane. Moreover, Only P-gp located in cell membrane can mediate MDR. And P-gp＇s expression and regulation is related to various signal pathways, such as MAPK, Wnt/β-catenin, PKC, NF-κB and so on. Researches have also confirmed that miRNAs are correlation with MDR. The intracellular transport of P-gp and research progress of P-gp＇s related signal pathway is reviewed, which may provide a novel strategy for MDR reversal reagents target to P-gp. |
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| Keywords: | P-gp multidrug resistance intracellular transport signal pathway miRNA |
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