| 干细胞的异常分化与肿瘤发生 |
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| 引用本文： | 张巧,杨哲,周春燕.干细胞的异常分化与肿瘤发生[J].生命的化学,2014(4):577-582. |
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| 作者姓名： | 张巧 杨哲 周春燕 |
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| 作者单位： | 北京大学基础医学院生物化学与分子生物学系,北京100191 |
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| 基金项目： | 国家自然科学基金项目（81071675;81170713：81370236）;北京市自然科学基金项目（5122021） |
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| 摘 要： | 干细胞是一类具有自我更新和多向分化潜能的细胞群体。越来越多的研究表明,干细胞异常分化可导致肿瘤。并且在肿瘤组织中存在部分细胞,它们具有干细胞的多种特性,被称为肿瘤干细胞(cancer stem cell,CSC)。肿瘤干细胞理论的提出,为肿瘤的治疗与研究提供了新的方向。本文综述了正常干细胞异常分化、肿瘤干细胞的存在和特性、肿瘤干细胞靶向治疗的前景及所面临的问题等方面的研究进展。
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| 关 键 词： | 干细胞 异常分化 肿瘤干细胞 靶向治疗 |
Relationship between abnormal differentiation of stem cells and tumorigenesis |
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| ZHANG Qiao,YANG Zhe,ZHOU Chunyan.Relationship between abnormal differentiation of stem cells and tumorigenesis[J].Chemistry of Life,2014(4):577-582. |
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| Authors: | ZHANG Qiao YANG Zhe ZHOU Chunyan |
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| Institution: | (Department of Biochemistry and Molecular Biology, College of Basic Medical Science, Peking University, Beijing 100191, China) |
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| Abstract: | Stem cells are a type of cell population with abilities of self-renewal and multiple-lineage differ-entiation potentials. A growing number of studies show that abnormal differentiation of stem cells may lead tocancer. Moreover, there is existing a type of cells in the tumor tissue, which are called cancer stem cells, havemultipotential stem cell nature. Cancer stem cell theory provides a new direction for the research and treat-ment of cancer. This review summarizes recent research progress of the abnormal differentiation of normalstem cells, the evidences of existence of cancer stem cells and their characters, and the research prospect aswell as challenges. |
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| Keywords: | stem cell abnormal differentiation cancer stem cell targeted therapy |
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