Making digit patterns in the vertebrate limb |
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Authors: | Tickle Cheryll |
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Affiliation: | Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK. c.a.tickle@dundee.ac.uk |
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Abstract: | The vertebrate limb has been a premier model for studying pattern formation - a striking digit pattern is formed in human hands, with a thumb forming at one edge and a little finger at the other. Classic embryological studies in different model organisms combined with new sophisticated techniques that integrate gene-expression patterns and cell behaviour have begun to shed light on the mechanisms that control digit patterning, and stimulate re-evaluation of the current models. |
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