Co-lethality studied as an asset against viral drug escape: the HIV protease case |
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| Authors: | Sophie Brouillet Thomas Valere Emmanuelle Ollivier Laurent Marsan Anne Vanet |
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| Institution: | 1.Atelier de Bio Informatique,Paris,France;2.Université Paris Diderot, Paris 7,Paris,France;3.Université Pierre et Marie Curie, UMR 7138, Paris 6,Paris,France;4.Université de Versailles Saint Quentin, UMR 8144,équipe AOC, Laboratoire PRiSM,Versailles,France;5.INSERM, U973,Paris,France |
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| Abstract: | Background Co-lethality, or synthetic lethality is the documented genetic situation where two, separately non-lethal mutations, become
lethal when combined in one genome. Each mutation is called a “synthetic lethal” (SL) or a co-lethal. Like invariant positions,
SL sets (SL linked couples) are choice targets for drug design against fast-escaping RNA viruses: mutational viral escape
by loss of affinity to the drug may induce (synthetic) lethality. |
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