Expression of human atrial natriuretic polypeptide gene in Cos 7 cells期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Expression of human atrial natriuretic polypeptide gene in Cos 7 cells

Authors:	N Iwai M Matsunaga K Ogawa A Matsumori H Yoshida E Ohta C Kawai

Affiliation:	1. The Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan;1. Department of Nephrology, Peking University Third Hospital, Beijing, China;2. Department of Nephrology, Princess Alexandra Hospital, Brisbane, Australia;3. Centre for Kidney Disease Research, The University of Queensland, Queensland, Australia;4. Translational Research Institute, Brisbane, Australia;1. Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan;2. Department of Internal Medicine, Wakakusa-Tatsuma Rehabilitation Hospital, Japan;3. Department of Cardiovascular Medicine, Shinshu University School of Medicine, Japan

Abstract:	Cos 7 cells transfected with human atrial natriuretic polypeptide (hANP) gene with SV40 enhancer and replication origin sequences expressed hANP gene. The expressed RNA was indistinguishable from native hANP mRNA and the transcribed protein seemed to be properly processed to alpha-hANP and beta-hANP. This system provides a useful approach to investigate the processing of hANPs and the structure-function relationship of amino acid sequences of hANPs.

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