MSH/ACTH4-10: a tool to differentiate between the role of vasopressin in memory consolidation or retrieval processes |
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Authors: | T van Wimersma Greidanus |
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Affiliation: | Rudolf Magnus Institute for Pharmacology, Medical Faculty, University of Utrecht Vondellaan 6, Utrecht, The Netherlands |
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Abstract: | MSH/ACTH4-10 induces a dose dependent increase of latency scores during retention of a passive avoidance response, when injected SC prior to retention but not when administered immediately after the learning trial. Intracerebroventricular administration of anti-vasopressin serum immediately after the learning trial or 1 hr prior to retention induces marked deficits in passive avoidance behavior as indicated by low latencies during retention. SC injection of MSH/ACTH4-10 increased latency scores in animals which received anti-vasopressin serum prior to retention, but did not alter latencies in animals, which received anti-vasopressin serum after the learning trial. These results suggest that MSH/ACTH4-10 is involved in retrieval processes and is able to differentiate between the effects of vasopressin on memory consolidation and on retrieval. |
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Keywords: | Vasopressin Memory |
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