XPA A23G polymorphism and susceptibility to cancer: a meta-analysis |
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Authors: | Jun Liu Zhen Zhang Xiao-Lin Cao Da-Peng Lei Zhong-Qiu Wang Tong Jin Xin-Liang Pan |
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Affiliation: | (1) Department of Otolaryngology, Qilu Hospital, Shandong University, No. 107 West Wenhua Road, Jinan, 250012, Shandong, People’s Republic of China;(2) Department of Neurosurgery, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, People’s Republic of China;(3) Department of Otolaryngology and Head & Neck Surgery, Hangzhou First People’s Hospital, Hangzhou, People’s Republic of China;(4) Department of Medical Imaging, Nanjing Jinling Hospital Medical School of Nanjing University, Nanjing, People’s Republic of China; |
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Abstract: | Xeroderma pigmentosum group A (XPA) participates in modulating recognition of DNA damage during the DNA nucleotide excision repair process. The XPA A23G polymorphism has been investigated in case–control studies to evaluate the cancer risk attributed to the variant, but the results were conflicting. To clarify the effect of XPA A23G polymorphism in cancer risk, we conducted a meta-analysis that included 30 published case–control studies. Overall, no significant association of XPA A23G variant with cancer susceptibility was observed for any genetic model. However, significant association was observed for colorectal cancer (GG vs. AA: OR = 1.68, 95% CI = 1.15–2.44; dominant genetic model GG + AG vs. AA: OR = 1.54, 95% CI = 1.08–1.17), for breast cancer an increased but non-significant risk was found (GG vs. AA: OR = 1.27, 95% CI = 0.98–1.66; dominant genetic model GG + AG vs. AA: OR = 1.27, 95% CI = 0.99–1.63), and for head and neck cancer an increased risk was observed in recessive model (OR = 1.19, 95% CI = 1.02–1.38), whereas for lung cancer a significant reduced risk was observed (GG vs. AA: OR = 0.77, 95% CI = 0.66–0.90; dominant genetic model GG + AG vs. AA: OR = 0.76, 95% CI = 0.66–0.87), it’s noting that in Asian population the inverse association was more apparent. In addition, in Asian population for esophageal cancer a significant decreased risk was also found in dominant genetic model (OR = 0.55; 95% CI = 0.43–0.70) and for head and neck cancer an increased risk was observed in dominant genetic model (OR = 1.51, 95% CI = 1.03–2.23). The meta-analysis suggested that the XPA A23G G allele is a low-penetrant risk factor for cancer development. |
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