诱导型一氧化氮合酶抑制剂研发现状

一氧化氮(NO)对炎症性疾病的治疗作用近来引起了广泛的重视。诱导型一氧化合成酶(iNOS)被发现广泛地参与趋炎因子表达和反应性氧化产物(ROS)/反应性氮化产物(RNS)的产生,从而进一步证明了一氧化氮在炎症病理发生发展中的关键作用。由于传统的抗炎药物环氧合酶-2(COX-2)抑制剂被报导有较多副作用,新型抑制炎症药物的研究开发势在必行。本文分别介绍了化学来源、生物来源、植物来原性iNOS抑制剂阻的开发、研究现状,阐述了其在断炎症信息传递通道中的作用。表明了iNOS抑制剂防止炎症损害的相关机理,提出iNOs不仅能在初始阶段影响炎症的发生,也对抑制和终结炎症有作用。最后进一步介绍了用中草药研发iNOs抑制剂的可能性,展望了于中药在该领域内的巨大前景。

Recent Studies on iNOS Inhibitors from Biological Sources

The roles of nitric oxide(NO)in the inflammatory diseases have been noticed recently.The recently identified regu- latory effect of inducible nitric oxide synthase(iNOS)on pro-inflammatory mediators and reactive oxygen species/reactive nitrogen species(ROS/RNS)further confirmed the key role of NO signaling in inflammation.Considering the increased reports of side effect of COX-2 inhibitor,a new generation of anti-inflammatory medicine is required for broad clinic usage.We have proposed the importance of developing iNOS inhibitor and demonstrated that iNOS inhibitor blocks the activation of inflammatory signaling pathway as well as pre- vents the organ injury associated with inflammation.Thus,iNOS is not only a final mediator of inflammation,but also essential for the initiation and promotion of the inflammatory response.Furthermore,in this review,we also introduced our efforts to discover serious iN- OS inhibitors from natural substance.