Sialidase and malignancy: A minireview |
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Authors: | Taeko Miyagi Tadashi Wada Kazunori Yamaguchi Keiko Hata |
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Institution: | (1) Division of Biochemistry, Research Institute, Miyagi Prefectural Cancer Center, Natori, Miyagi 981-1293, Japan |
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Abstract: | Aberrant sialylation in cancer cells is thought to be a characteristic feature associated with malignant properties including
invasiveness and metastatic potential. Sialidase which catalyzes the removal of sialic acid residues from glycoproteins and
glycolipids, has been suggested to play important roles in many biological processes through regulation of cellular sialic
acid contents. The altered expression of sialidase observed in cancer would, therefore, suggest its involvement in the malignant
process. In mammalian cells, three types of sialidase cloned and characterized to date were found to behave in different manners
during carcinogenesis. Recent progress in molecular cloning of these sialidases has facilitated elucidation of the molecular
mechanisms and significance of these alterations. Herein we briefly describe our own studies on sialidase changes associated
with malignant transformation and summarize the topic from both a retrospective and a prospective viewpoint. Sialidases are
indeed closely related to malignancy and are thus potential targets for cancer diagnosis and therapy. Published in 2004.
This revised version was published online in August 2006 with corrections to the Cover Date. |
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Keywords: | sialidase sialic acid cancer metastasis glycosylation sialylation glycoprotein ganglioside |
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