Passive administration of monoclonal antibodies to Anthrolysin O prolong survival in mice lethally infected with <Emphasis Type="Italic">Bacillus anthracis</Emphasis> |
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| Authors: | Antonio Nakouzi Johanna Rivera Richard F Rest Arturo Casadevall |
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| Institution: | (1) Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461 Bronx, New York, USA;(2) Department of Medicine (Division of Infectious Diseases), Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461 Bronx, New York, USA;(3) Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, 19129 Philadelphia, PA, USA |
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| Abstract: | Background
Bacillus anthracis has two major virulence factors: a tripartite toxin that produces lethal and edema toxins and a polyglutamic acid capsule.
A recent report suggested that a toxin belonging to the cholesterol dependant cytolysin (CDC) family, anthrolysin O (ALO)
was a new virulence factor for B. anthracis but subsequent studies have questioned its relevance in pathogenesis. In this study, we examined the immunogenicity of recombinant
anthrolysin O (rALO) in mice. |
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