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The mitochondrial megachannel is the permeability transition pore
Authors:Ildikó Szabó  Mario Zoratti
Institution:(1) Consiglio Nazionale delle Ricerche, Centro Studi Fisiologia Mitocondri, Istituto di Patologia Generale, Via Trieste 75, 35121 Padova, Italy
Abstract:Single-channel electrophysiological recordings from rat liver mitoplast membranes showed that the 1.3-nS mitochondrial megachannel was activated by Ca++ and inhibited by Mg++, Cyclosporin A, and ADP, probably acting at matrix-side sites. These agents are known to modulate the so-called mitochondrial permeability transition pore (Gunter, T. E., and Pfeiffer, D. R. (1990)Am. J. Physiol. 258, C755–C786) in the same manner. Furthermore, the megachannel is unselective, and the minimum pore size calculated from its conductance is in agreement with independent estimates of the minimum size of the permeabilization pore. The results support the tentative identification of the megachannel with the pore believed to be involved in the permeabilization process.Abbreviations used: PT: permeability transition; PTP: permeability transition pore; MMC: mitochondrial megachannel; IMAC: inner membrane anion channel. PA: permeability of ion A. CSP: Cyclosporin A.
Keywords:Mitochondrial channels  selectivity  patch-clamp  permeability transition  calcium  magnesium  Cyclosporin A (rat liver mitochondria)
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