Free radical scavenging activity of novel thiazolidine‐2,4‐dione derivatives |
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Authors: | Pawe? Berczyński Irena Kruk Teresa Piechowska Meltem Ceylan‐Unlusoy Oya Bozda?‐Dündar Hassan Y Aboul‐Enein |
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Institution: | 1. Institute of Physics, Faculty of Mechanical Engineering and Mechatronics, West Pomeranian University of Technology in Szczecin, , 70‐311 Szczecin, Poland;2. Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, , 06100, Ankara, Turkey;3. Pharmaceutical and Medicinal Chemistry Department, The Pharmaceutical and Drug Industries Research Division, National Research Centre, , Cairo, 12311 Egypt |
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Abstract: | Free radical activity towards superoxide anion radical (), hydroxyl radical (HO?) and 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH?) of a series of novel thiazolidine‐2,4‐dione derivatives (TSs) was examined using chemiluminescence, electron paramagnetic resonance (EPR) and EPR spin trapping techniques. 5,5‐Dimethyl‐1‐pyrroline‐N‐oxide (DMPO) was applied as the spin trap. Superoxide radical was produced in the potassium superoxide/18‐crown‐6 ether dissolved in dimethyl sulfoxide. Hydroxyl radical was generated in the Fenton reaction (Fe(II) + H2O2. It was found that TSs showed a slight scavenging effect (15–38% reduction at 2.5 mmol/L concentration) of the DPPH radical and a high scavenging effect of (41–88%). The tested compounds showed inhibition of HO? ‐dependent DMPO‐OH spin adduct formation (the amplitude of EPR signal decrease ranged from 20 to 76% at 2.5 mmol/L concentration. Our findings present new group compounds of relatively high reactivity towards free radicals. Copyright © 2012 John Wiley & Sons, Ltd. |
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Keywords: | 1 1‐diphenyl‐2‐picrylhydoxyl radical chemiluminescence EPR hydroxyl radical spin trapping superoxide radical thiazolidine 2 4‐dione derivatives |
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