CRISPR‐Cas |
| |
Authors: | Prof Dr Anita Marchfelder Lisa‐Katharina Maier Nadja Heidrich Dr Ümit Pul |
| |
Institution: | 1. Biologie II, Universit?t Ulm, 89069 Ulm;2. Institut für Molekulare Infektionsbiologie der Universit?t Würzburg;3. Physikalische Biologie, Heinrich‐Heine‐Universit?t Düsseldorf, 40225 Düsseldorf |
| |
Abstract: | The prokaryotic immune system: CRISPR‐Cas The struggle of survival between prokaryotes and their viruses is likely one of the oldest conflicts on earth. Prokaryotes have developed different defense strategies to fend off an infection by the ubiquitous viruses that outnumber prokaryotes by an estimated factor of 10. Viruses, in turn, exhibit several counter mechanisms to overcome the prokaryotic defense. The recently discovered CRISPR‐Cas‐system represents a remarkable example for the continuous arms race between prokaryotes and viruses. Originally discovered in prokaryotes, the CRISPR‐Cas‐mediated defense constitutes an adaptive and heritable immune system against viruses and plasmids. |
| |
Keywords: | prokaryotische Immunantwort CRISPR‐Cas Viren Archaea Bakterien |
|
|