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The challenge of improved secretory production of active pharmaceutical ingredients in Saccharomyces cerevisiae: A case study on human insulin analogs |
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| Authors: | Ali Kazemi Seresht Eva A Palmqvist Gerd Schluckebier Ingrid Pettersson Lisbeth Olsson |
| Institution: | 1. Industrial Biotechnology, Department of Chemical and Biological Engineering, Chalmers University of Technology, , Gothenburg, Sweden;2. Diabetes Protein Engineering, Diabetes Research Unit, Novo Nordisk A/S, , DK‐2780 M?l?v, Denmark;3. +45 30799102+45 4449 0555 |
| Abstract: | |
| Keywords: | heterologous protein production ER‐associated protein degradation chemostat cultivation microarray analysis insulin structure chromosome IV enrichment |