CdS nanoparticles‐ enhanced chemiluminescence and determination of baicalin in pharmaceutical preparations |
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| Authors: | Xiaolan Chen Xinmei Tan Jianxiu Wang |
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| Affiliation: | 1. College of Chemistry and Chemical Engineering, Central South University, , Changsha, Hunan, People's Republic of China;2. Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, , Xiangtan, Hunan, People's Republic of China |
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| Abstract: | CdS nanoparticles (CdS NPs) of different sizes were synthesized by the citrate reduction method. It was found that CdS NPs could enhance the chemiluminescence (CL) of the luminol‐potassium ferricyanide system and baicalin could inhibit CdS NPs‐enhanced luminol‐potassium ferricyanide CL signals in alkaline solution. Based on this inhibition, a flow‐injection CL method was established for determination of baicalin in pharmaceutical preparations and human urine samples. Under optimized conditions, the linear range for determination of baicalin was 5.0 x 10?6 to 1.0 x 10?3 g/L. The detection limit at a signal‐to‐noise ratio of 3 was 1.7 x 10 ?6 g/L. CL spectra, UV‐visible spectra and transmission electron microscopy (TEM) were used to investigate the CL mechanism. The method described is simple, selective and obviates the need of extensive sample pretreatment. Copyright © 2012 John Wiley & Sons, Ltd. |
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| Keywords: | CdS nanoparticles chemiluminescence baicalin pharmaceutical preparations |
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