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Effect of cell culture medium components on color of formulated monoclonal antibody drug substance
Authors:Natarajan Vijayasankaran  Sharat Varma  Yi Yang  Melissa Mun  Silvana Arevalo  Martin Gawlitzek  Trevor Swartz  Amy Lim  Feng Li  Boyan Zhang  Steve Meier  Robert Kiss
Affiliation:1. Late Stage Cell Culture, Genentech Inc., , South San Francisco, CA, 94080;2. Protein Analytical Chemistry, Genentech Inc., , South San Francisco, CA, 94080;3. Early Stage Pharmaceutical Development, Genentech Inc., , South San Francisco, CA, 94080;4. Purification Development, Genentech Inc., , South San Francisco, CA, 94080;5. Oceanside Pharma Technical Development, Genentech, Inc., , Oceanside, CA, 92056
Abstract:
Keywords:protein color  cell culture  fed‐batch  antibody  medium optimization  B2  B6  B9  B12  iron  CHO  ferrous sulfate
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