Anti-angiogenic activity of tocotrienol |
| |
| Authors: | Inokuchi Hitoshi Hirokane Hisako Tsuzuki Tsuyoshi Nakagawa Kiyotaka Igarashi Miki Miyazawa Teruo |
| |
| Institution: | Food & Biodynamic Chemistry Laboratory, Graduate School of Life Science and Agriculture, Tohok University, Sendai, Japan. |
| |
| Abstract: | The anti-angiogenic property of vitamin E compounds, with particular emphasis on tocotrienol, has been investigated in vitro. Tocotrienol, but not tocopherol, inhibited both the proliferation and tube formation of bovine aortic endothelial cells, with delta-tocotrienol appearing the highest activity. Also, delta-tocotrienol reduced the vascular endothelial growth factor-stimulated tube formation by human umbilical vein endothelial cells. Our findings suggest that tocotrienol has potential use as a therapeutic dietary supplement for minimizing tumor angiogenesis. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
