Silicon intake to vertebral columns of mice after dietary supply |
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Authors: | Atsuko Izu Tsukasa Kumai Yoshiyuki Tohno Setsuko Tohno Takeshi Minami Gen Yamada Masa-oki Yamada |
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Institution: | (1) Department of Anatomy, Nara Medical University, 634-8521 Kashihara, Japan;(2) Laboratory of Environmental Biology, Department of Life Science, School of Science & Engineering, Kinki University, 577-8502 Higashi-Osaka, Japan;(3) Center for Animal Resources and Development, Kumamoto University, 860-0811 Kumamoto, Japan |
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Abstract: | Vertebral columns were dissected and analyzed after birth with oral administration of silicon for 4 wk and for 8 wk. The silicon
level was lower (20 μg/g) at the beginning. It remains unchanged after 4 wk and then increases twice as much as that for those
mice bred for 8 wk than those bred for 4 wk. This increase depends remarkably on the mass ratio of Si/Ca (M/M). The ratio increases to three times higher than that of the control at the beginning of the experiments (5 wk after birth).
Although the S and P contents appeared to be lower, these increased when Si was administered in combination with phosphopeptide.
Other elements, such as Ca, Mg, Fe, and Zn, appeared to be unchanged as the weeks proceeded. These findings seem to support
a proposal that silicon is necessary for the growth of backbones in mice. |
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Keywords: | Silicon bone Si backbone Si intake mouse vertebra |
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