Novel biotechnology approaches in colorectal cancer diagnosis and therapy |
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Authors: | Soudabeh Kavousipour Fathemeh Khademi Mozhdeh Zamani Bahareh Vakili Pooneh Mokarram |
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Institution: | 1.Department of Biotechnology, School of Advanced Medical Science and Technologies,Shiraz University of Medical Sciences,Shiraz,Iran;2.Department of Biochemistry, School of Medicine,Shiraz University of Medical Sciences,Shiraz,Iran;3.Colorectal Research Center,Shiraz University of Medical Sciences,Shiraz,Iran;4.School of Medicine, Nemazee Hospital, Gastroenterohepatology Research Center,Shiraz University of Medical Sciences,Shiraz,Iran |
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Abstract: | With ever-increasing molecular information about colorectal cancer (CRC), there is an expectation to detect more sensitive and specific molecular markers for new advanced diagnostic methods that can surpass the limitations of current screening tests. Moreover, enhanced molecular pathology knowledge about cancer has led to the development of targeted therapies, designed to interfere with specific aberrant biological pathways in cancer. Furthermore, biotechnology has opened a new window in CRC diagnosis and treatment by introducing different application of antibodies, antibody fragments, non-Ig scaffold proteins, and aptamers in targeted therapy and drug delivery. This review summarizes the molecular diagnostic and therapeutic approaches in CRC with a focus on genetic and epigenetic alterations, protein and metabolite markers as well as targeted therapy and drug delivery by Ig-scaffold proteins, non-Ig scaffold proteins, nanobodies, and aptamers. |
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