The Use of Exosomes as Biomarkers for Evaluating and Monitoring Critically Ill Polytrauma Patients with Sepsis |
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| Authors: | Marian Ticlea Lavinia Melania Bratu Florian Bodog Ovidiu Horea Bedreag Alexandru Florin Rogobete Zorin Petrisor Crainiceanu |
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| Institution: | 1.Faculty of Medicine and Pharmacy Oradea,University of Oradea,Oradea,Romania;2.Faculty of Pharmacy,“Victor Babes” University of Medicine and Pharmacy,Timisoara,Romania;3.Faculty of Medicine,“Victor Babes” University of Medicine and Pharmacy,Timisoara,Romania;4.Clinic of Anesthesia and Intensive Care,Emergency County Hospital “Pius Brinzeu” Timisoara,Timisoara,Romania |
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| Abstract: | Regarding genetic biomarkers for early assessment and monitoring the clinical course in polytrauma patients with sepsis, in recent years a remarkable evolution has been highlighted. One of the main representatives is the exosome miRNAs. In this paper, we would like to present in more details the various methods of using exosome miRNAs as a biomarker for monitoring polytrauma patients with sepsis, as well as establishing a belated outcome by aggregating the entire clinical aspects. The use of exosome miRNAs for late evaluating and monitoring the clinical evolution of polytrauma patients can bring significant improvements in current clinical practice through the optimization and modulation of intensive care according to the needs of each patient individually. |
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