Interplay Between Autophagy and Zinc |
| |
Affiliation: | 1. Department of Molecular Biology, Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad, 500016 Telangana, India;2. Department of Biochemistry, Kakatiya University, Warangal 506009, Telangana, India;3. Department of Biotechnology, KL University, Vaddeswaram, Guntur, 522502 Andhra Pradesh, India |
| |
Abstract: | Autophagy is a conserved catabolic process that plays an important role in cellular homeostasis. The study of the interplay between autophagy and zinc has gained interest over the last years. Multiple studies have indicated that zinc stimulates autophagy and is critical for basal and induced autophagy in mammalian cells. Conversely, autophagy is induced by zinc starvation in yeast. There are no studies analyzing the role of zinc in either Microautophagy or Chaperone-Mediated-Autophagy. The mechanisms by which zinc modulates autophagy are still poorly understood. Studies examining loss of function of genes involved in cellular zinc homeostasis have provided novel insights into the role of zinc in autophagy. Autophagy may help cells adapt to changes in zinc availability in medium by controlling zinc mobilization, recycling, and secretion. Zinc is a key player in toxic and protective autophagy. |
| |
Keywords: | Autophagy Zinc Metallothioneins Mitophagy Lysosome |
本文献已被 ScienceDirect 等数据库收录! |
|