Recent advances in clinical studies of selenium supplementation in radiotherapy |
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| Affiliation: | 1. Department of Public Health, Gunma University Graduate School of Medicine, Maebashi, Japan;2. Department of Pharmacology and Clinical Pharmacy, Universitas Padjadjaran, Bandung, Indonesia;3. Department of Nutrition, Koshien University, Takarazuka, Japan;4. Quantum Medical Science Directorate, National Institute for Quantum and Radiological Science and Technology, Chiba, Japan;1. School of Medicine, Universidad Panamericana, Mexico City, Mexico;2. Univerisidad de Papaloapan, Oaxaca, Mexico;3. Laboratory of Developmental Biology Research and Experimental Teratogenicity. Children’s Hospital of Mexico Federico Gomez (HIMFG), Mexico City, Mexico;1. Department of Biochemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat 390002, India;2. Biotechnology, School of Science, GSFC University, Vadodara, 391750, India;1. Institute of Human Nutrition and Dietetics, Poznan University of Life Sciences, Wojska Polskiego 31, 60-624 Poznan, Poland;2. Department of Animal Physiology and Biochemistry, Poznan University of Life Sciences, 35 Wolynska Street, 60-637 Poznan, Poland;1. Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey;2. Department of Child and Adolescent Psychiatry, Faculty of Medicine, Hacettepe University, Ankara, Turkey;3. Department of Food Hygiene and Technology, Faculty of Veterinary Medicine, Selçuk University, Konya, Turkey;1. Wageningen University and Research, Department of Environmental Sciences, Box 47, 6700 AA, Wageningen, the Netherlands;2. Radboud University, Institute for Water and Wetland Research, Dept. Animal Ecology and Physiology, Box 9010, 6500 GL Nijmegen, the Netherlands;3. Smithsonian Tropical Research Institute, Center for Tropical Forest Science, Balboa, Ancon, Panama |
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| Abstract: | BackgroundRadiotherapy is one of the most important and common therapies for cancer patients. Selenium has been shown to be capable of reducing the side effects of radiotherapy because selenoproteins have anti-oxidative functions against reactive oxygen species that are induced by the radiation. They also function in DNA-repair and cytokine control.PurposeWe explored the benefits and risks of selenium supplementation in radiotherapy in our previous review to establish guidelines. In the current study, we expanded the search to cover recent advances in clinical studies of selenium supplementation in radiotherapy.MethodsWe conducted an initial screening in the PubMed using the MeSH terms and keywords “selenium”, “radiation”, “therapy”, and “radiotherapy” using the same methodology applied in our previous review. We identified 121 articles published between January 2013 and December 2019. We then identified eight articles (six studies) on selenium and radiotherapy by excluding 113 articles.ResultsIn selenium supplementation studies, selenium doses of 300−500 μg/day with duration of 10 days to 6 months were used. Selenium supplementation improved the selenium nutritional conditions of the patients and reduced the side effects of radiotherapy. Selenium supplementation did not reduce the effectiveness of radiotherapy, and no toxicities were reported.ConclusionThe results of our previous and current reviews showed that selenium supplementation offers specific benefits for several cancer types treated with radiotherapy. Here, we suggest a new guideline for selenium supplementation in radiotherapy. We recommend determining the selenium status of the patients before radiotherapy, and in cases of deficiency (<100 μg/L serum selenium level), selenium supplement can be beneficial. |
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| Keywords: | Selenium Supplementation Clinical studies Radiotherapy |
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