“Make way”: Pathogen exploitation of membrane traffic |
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| Institution: | 1. Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, 94143, USA;2. George Williams Hooper Foundation, University of California, San Francisco, San Francisco, CA, 94143, USA;1. Weill Institute for Cell and Molecular Biology and Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA;1. Department of Molecular Genetics & Microbiology, Duke University Medical Center, Durham, NC 27710, USA;2. Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA;3. Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA;4. Program in Emerging Infectious Diseases, Duke-National University of Singapore, Singapore 169857, Singapore;1. Howard Hughes Medical Institute, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, United States;2. Department of Microbiology and Molecular Biology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, United States |
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| Abstract: | Intracellular pathogens have evolved numerous strategies to manipulate their host cells to survive and replicate in a hostile environment. They often exploit membrane trafficking pathways to enter the cell, establish a replicative niche, avoid degradation and immune response, acquire nutrients and lastly, egress. Recent studies on membrane trafficking exploitation by intracellular pathogens have led to the discovery of novel and fascinating cell biology, including a noncanonical mechanism of ubiquitination and a novel mitophagy receptor. Thus, studying how pathogens target host cell membrane trafficking pathways is not only important for the development of new therapeutics, but also helps understanding fundamental mechanisms of cell biology. |
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| Keywords: | Membrane trafficking Host-pathogen interactions Legionella Flavivirus Secretory pathway Autophagy |
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