Quercetin alleviates rheumatoid arthritis by inhibiting neutrophil inflammatory activities |
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| Affiliation: | 1. Collaborative Innovation Center of Miao medicine, Guiyang College of Traditional Chinese Medicine, Guiyang, Guizhou, China;2. State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China;3. Department of Hematology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China;4. Department of the first Orthopedics, The 2nd Affiliated Hospital, Guiyang College of Traditional Chinese Medicine, Guiyang, Guizhou, China;1. Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China;2. School of Traditional Chinese Medicine, Jinan University, Guangzhou, Guangdong, China;3. School of Traditional Chinese Medicine, the Southern Medical University, Guangzhou, Guangdong, China;4. Department of Rheumatology, the First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China;1. Department of Outpatient Pharmacy, The First People''s Hospital of Wenling, Wenling 317500, Zhejiang, China;2. Department of Pharmacy, The First People''s Hospital of Wenling, Wenling 317500, Zhejiang, China;1. Department of Pathology, Center of Biological Sciences, State University of Londrina, 86057-970, Londrina, Paraná, Brazil;2. Laboratory of Immunology and Molecular Biology, São Leopoldo Mandic Institute and Research Center, 13045-755, Campinas, São Paulo, Brazil;3. Department of Morphology, Physiology and Basic Pathology, School of Dentistry, University of São Paulo, 14040-903, Ribeirão Preto, São Paulo, Brazil;4. Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, 14040-903, Ribeirão Preto, São Paulo, Brazil;5. Department of Pharmaceutical Sciences, University Hospital (Health Science Centre), Londrina State University, 86038-350, Londrina, Paraná, Brazil |
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| Abstract: | Rheumatoid arthritis (RA) is a prototypical autoimmune disorder mainly characterized by joint inflammation and cartilage destruction. Neutrophils actively take part in the initiation and progression of RA. Neutrophils express inflammatory mediators, including cytokines and chemokines. Aberrant formation of neutrophil extracellular traps (NETs) has been demonstrated in the pathogenesis of RA. Thus, neutrophils are regarded as important therapeutic targets in RA treatment. Quercetin is one of the major flavonoids found in fruits and vegetables. Previous studies have demonstrated that quercetin is a potential agent for the treatment of RA. However, the underlying antiarthritic mechanism of quercetin has not been investigated clearly. In this study, we analyzed the therapeutic mechanism of quercetin for RA. Our results showed that quercetin ameliorates inflammation in RA mice by inhibiting neutrophil activities. Quercetin inhibited neutrophil infiltration and reduced the plasma levels of inflammatory cytokines. Quercetin promoted the apoptosis of activated neutrophils. In addition, quercetin inhibited NET formation by suppressing autophagy. These findings suggest that quercetin may be an alternative agent for the treatment of RA by inhibiting neutrophil activities. |
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