Lower strontium in two different body matrices in neurodevelopmental disorders: A preliminary report |
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| Institution: | 1. Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey;2. Department of Child and Adolescent Psychiatry, Faculty of Medicine, Hacettepe University, Ankara, Turkey;3. Department of Food Hygiene and Technology, Faculty of Veterinary Medicine, Selçuk University, Konya, Turkey;1. School of Medicine, Universidad Panamericana, Mexico City, Mexico;2. Univerisidad de Papaloapan, Oaxaca, Mexico;3. Laboratory of Developmental Biology Research and Experimental Teratogenicity. Children’s Hospital of Mexico Federico Gomez (HIMFG), Mexico City, Mexico;1. Center for Occupational and Environmental Health, Department of Medicine, University of California, Irvine, CA, USA;2. Department of Biological Chemistry, University of California, Irvine, CA, USA;3. Nash Family Department of Neuroscience, Ronald M. Loeb Center for Alzheimer’s Disease, Icahn School of Medicine at Mount Sinai, NY, USA;1. Vila Velha University – UVV, Laboratory of Applied Ichthyology (LAB PEIXE), Comissário José Dantas de Melo, 21, Boa Vista, 29102-770, Vila Velha, ES, Brazil;2. Federal University of Espírito Santo - UFES, Department of Chemistry, Fernando Ferrari, 514, Goiabeiras, 29075-910, Vitória, ES, Brazil;1. Department of Biochemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat 390002, India;2. Biotechnology, School of Science, GSFC University, Vadodara, 391750, India;1. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran;2. Department of Pathology, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran;3. Department of Psychology, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran;1. Institute of Human Nutrition and Dietetics, Poznan University of Life Sciences, Wojska Polskiego 31, 60-624 Poznan, Poland;2. Department of Animal Physiology and Biochemistry, Poznan University of Life Sciences, 35 Wolynska Street, 60-637 Poznan, Poland |
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| Abstract: | BackgroundEnvironmental factors, including elemental homeostasis, have not been studied sufficiently in neurodevelopmental disorders (NDD). This study aims to compare the status of 13 elements in blood and deciduous teeth dentine of children having an autism spectrum disorder or attention deficit hyperactivity disorder with typically developing controls.MethodsElements including calcium, phosphorus, magnesium, iron, zinc, copper, chromium, manganese, mercury, lead, cadmium, molybdenum, and strontium in both deciduous teeth and blood were analyzed by inductively coupled plasma mass spectrometry.ResultsStrontium levels in both blood and teeth samples were found to be significantly lower in the NDD group. Additionally, blood cadmium and mercury levels, and copper/zinc ratio were higher in the NDD group.ConclusionsOur results warrant further investigation in a large series of NDD examining symptom levels and genetic variations associated with elemental homeostasis. |
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| Keywords: | Trace elements Heavy metals Autism spectrum disorders Attention deficit hyperactivity disorder Teeth Blood |
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