The multifunctional nature of mitochondrial contact site proteins |
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| Affiliation: | 1. Institut für Zellbiologie, Universität Bayreuth, 95440 Bayreuth, Germany;1. UCL Institute of Ophthalmology, 11–43 Bath Street, London EC1V 9EL, UK;1. Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel;2. Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 7610001, Israel;3. Electron Microscopy Unit, Weizmann Institute of Science, Rehovot 7610001, Israel;4. Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel;1. Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA;2. Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Evanston, IL 60208, USA;1. Biochemistry Section, Department of Biology/Chemistry, University of Osnabrück, Barbarastrasse 13, 49076 Osnabrück, Germany;2. Department of Cell Biology, Center for Molecular Medicine, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands;3. Institute for Biochemistry and Molecular Biology, ZBMZ, and BIOSS Centre for Biological Signalling Studies, University of Freiburg, Stefan-Meier-Strasse 17, 79104 Freiburg, Germany;4. Molecular Cell Biology, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands |
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| Abstract: | Mitochondria make physical contact with nearly every other membrane in the cell, and these contacts have a wide variety of functions that are carried out by proteins that reside at the sites of contact. Over the past decade, tremendous insight into the identity and functions of proteins localized to mitochondrial contact sites has been gained. In doing so, it has become clear that one protein or protein complex can contribute to contact site formation and function in a wide variety of ways. Thus, complex and often surprising relationships between the roles of a mitochondrial contact site and its multifunctional resident proteins continue to be unraveled. |
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| Keywords: | Mitochondria Membrane contact sites Mitochondrial contact sites |
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