Boron supplementation in peripartum Murrah buffaloes: The effect on calcium homeostasis,bone metabolism,endocrine and antioxidant status |
| |
| Affiliation: | 1. Consultants unit, Research and Consulting Institute, King Faisal University, P.O Box 400, Al-Ahsa 31982, Saudi Arabia;2. Sudan Atomic Energy Commission, Khartoum, Sudan;3. Department of Chemistry, College of Science, King Khalid University, Abha 61321, Saudi Arabia;4. Research Center for Advance Materials Science (RCAMS), King Khalid University, Abha 1413, P.O. Box 9004, Saudi Arabia;5. Department of Chemistry, College of Science, King Faisal University, P.O Box 400, Al-Ahsa 31982, Saudi Arabia;6. Research Unit Analytical BioGeoChemistry, Helmholtz Center, Munich, German Research Center for Environmental Health, Neuherberg, Germany;1. School of Medicine, Universidad Panamericana, Mexico City, Mexico;2. Univerisidad de Papaloapan, Oaxaca, Mexico;3. Laboratory of Developmental Biology Research and Experimental Teratogenicity. Children’s Hospital of Mexico Federico Gomez (HIMFG), Mexico City, Mexico;1. Mineral and Vitamin Nutrition Laboratory, Centre for Advanced Faculty Training in Animal Nutrition, ICAR-Indian Veterinary Research Institute, Izatnagar, 243 122, UP, India;2. Biological Standardization Division, ICAR-Indian Veterinary Research Institute, Izatnagar, 243 122, UP, India;1. Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey;2. Department of Food Hygiene and Technology, Faculty of Veterinary Medicine, Selçuk University, Konya, Turkey;1. Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, 96813, USA;2. Department of Internal Medicine, Faculty of Medicine of Ribeirão Preto, University of São Paulo – FMRP/USP, Brazil;1. Center for Basic Medical Research & Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China;2. Unit of Perfusion, Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China;3. Department of Cardiovascular Surgery, The First Affiliated Hospital, Zhejiang University, Hangzhou, China;4. School of Pharmacy, Wannan Medical College, Wuhu, China;5. Department of Surgery, Oregon Health and Science University, Portland, Oregon, USA |
| |
| Abstract: | BackgroundCalcium homeostasis and immuno-endocrine system undergoes drastic changes in peripartum dairy animals and failure to adapt these physiological changes causes major impact on animal health as well as productivity. Boron (B), a newer trace element, influences calcium (Ca), phosphorus (P) and magnesium (Mg) metabolism as well as immune system by manipulating several hormones or enzyme systems. Present study was conducted to determine the effect of dietary B supplementation on Ca homeostasis, bone metabolism, endocrine and antioxidant status in peripartum Murrah buffaloes.MethodsThirty advanced pregnant Murrah buffaloes (8th month pregnant) were allocated into three groups based on their most probable producing ability (MPPA) and parity (n = 10 in each group) viz. B0, B200 and B400 and supplemented with 0, 200 and 400 ppm of B in the form of boric acid. Blood samples were collected at periodic intervals (-45, -30, -21, -15, -7, 0, 7, 15, 30, 60, 90 and 120 day relative to expected date of calving) and analysed for minerals concentration, hormonal profile, bone health biomarkers and antioxidant enzymes.Results and conclusionBoron supplementation at 200 and 400 ppm increased (p < 0.05) plasma Ca, Mg and osteocalcin (OCN) concentration during postpartum stage. Higher (p < 0.05) levels of plasma 25-hydroxy vitamin D3 were observed in both B supplemented groups as compared to B unsupplemented group irrespective of physiological stages. Plasma parathyroid hormone (PTH) and cortisol levels were lower (p < 0.05) in both B supplemented groups than B unsupplemented group, especially during postpartum stage. Whereas, plasma ferric reducing total antioxidant power (FRAP) activity was found to be higher (p < 0.05) in B supplemented groups as compared to B unsupplemented group. Furthermore, antioxidant enzymes (erythrocytic superoxide dismutase; SOD, catalase, glutathione peroxidase; GPx), plasma level of total immunoglobulins (TIg), bone specific alkaline phosphatase (BALP) and tartrate resistant acid phosphatase (TRAP) remained unaffected by dietary B supplementation. Overall, it can be concluded that supplementation of B at 200 ppm in the diet of peripartum Murrah buffaloes helped to induce metabolic adaptations for improving Ca homeostasis, bone metabolism and antioxidant status without much additional benefits at higher level used in the present study. |
| |
| Keywords: | Boron Murrah buffaloes Immunity Antioxidant Endocrine status Calcium |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
