Effect of sodium molybdate on cadmium-related testicular damage in adult male Wistar rats |
| |
| Affiliation: | 1. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran;2. Department of Pathology, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran;3. Department of Psychology, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran;1. Consultants unit, Research and Consulting Institute, King Faisal University, P.O Box 400, Al-Ahsa 31982, Saudi Arabia;2. Sudan Atomic Energy Commission, Khartoum, Sudan;3. Department of Chemistry, College of Science, King Khalid University, Abha 61321, Saudi Arabia;4. Research Center for Advance Materials Science (RCAMS), King Khalid University, Abha 1413, P.O. Box 9004, Saudi Arabia;5. Department of Chemistry, College of Science, King Faisal University, P.O Box 400, Al-Ahsa 31982, Saudi Arabia;6. Research Unit Analytical BioGeoChemistry, Helmholtz Center, Munich, German Research Center for Environmental Health, Neuherberg, Germany;1. Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, 96813, USA;2. Department of Internal Medicine, Faculty of Medicine of Ribeirão Preto, University of São Paulo – FMRP/USP, Brazil;1. Center for Basic Medical Research & Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China;2. Unit of Perfusion, Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China;3. Department of Cardiovascular Surgery, The First Affiliated Hospital, Zhejiang University, Hangzhou, China;4. School of Pharmacy, Wannan Medical College, Wuhu, China;5. Department of Surgery, Oregon Health and Science University, Portland, Oregon, USA;1. Vila Velha University – UVV, Laboratory of Applied Ichthyology (LAB PEIXE), Comissário José Dantas de Melo, 21, Boa Vista, 29102-770, Vila Velha, ES, Brazil;2. Federal University of Espírito Santo - UFES, Department of Chemistry, Fernando Ferrari, 514, Goiabeiras, 29075-910, Vitória, ES, Brazil;1. Cardinal Stefan Wyszyński University, Faculty of Medical Science, Collegium Medicum, Warsaw, Poland;2. Institute of Psychiatry and Neurology, Second Department of Neurology, Warsaw, Poland;3. Medical University in Warsaw, Department of Gastroenterology and Internal Medicine, Warsaw, Poland |
| |
| Abstract: | BackgroundMolybdenum, as a trace element, has various pharmacological effects, including antioxidant, antiviral, anti-allergic, anti-osteoporosis, anti-tumor, anti-inflammatory, anti-diabetic, anti-obesity, and free radical-scavenging activities. This study aimed at investigating the sodium molybdate impacts on cadmium chloride (CdCl2)-induced testicular toxicity in adult Wistar rats.MethodsThe impacts of oral administration of sodium molybdate (0.05, 0.1, 0.2, and 0.4 mg/kg) was evaluated in healthy and infertile animals. Animals were randomly assigned to nine groups, including healthy control, sodium molybdate alone, infertile control (3 mg/kg of CdCl2), and sodium molybdate plus CdCl2. Following 30 days of administration, animals were sacrificed for biochemical and histopathological assays.ResultsThe results indicated that administration of sodium molybdate to infertile rats significantly mitigated the cadmium impacts on sperm appearance, concentration, and motility parameters. Also, sodium molybdate reduced the production of malondialdehyde (MDA) and enhanced antioxidant enzymes activities in the testicular homogenates in rats; these findings were supported by histopathological examinations. Treatment with sodium molybdate significantly increased aquaporin-9 (AQP9) expression in the testicular tissues of infertile rats.ConclusionsThe current findings suggested that sodium molybdate performs as a strong protective agent from CdCl2-related testicular toxicity in rats. |
| |
| Keywords: | Molybdate Infertility Cadmium Rat |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
