Caesalpinia palmeri: First Report on the Phenolic Compounds Profile,Antioxidant and Cytotoxicity Effect |
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| Authors: | J. C. López-Romero H. Torres-Moreno M. Vidal-Gutiérrez G. G. Cabrera-Cabrera R. E. Robles-Zepeda K. L. Rodríguez-Martínez J. Ortega-García M. A. Villegas-Ochoa Norma J. Salazar-López J. Abraham Domínguez-Avila G. A. González-Aguilar |
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| Affiliation: | 1. Departamento de Ciencias Químico Biológicas y Agropecuarias, Universidad de Sonora, Unidad Regional Norte, Ave. Universidad e Irigoyen, H. Caborca, 83600 Sonora, México;2. Departamento de Ciencias Químico Biológicas y Agropecuarias, Universidad de Sonora, Unidad Regional Sur, Lazaro Cardenas de Rio No. 100 Col. Francisco Villa, Navojoa, Sonora, México;3. Departamento de Ciencias Químico Biológicas, Universidad de Sonora, Blvd. Luis Encinas y Rosales, 83000 Hermosillo, Sonora, México;4. Licenciatura en Nutrición Humana, Universidad Estatal de Sonora, Unidad Académica Hermosillo, 83100 Hermosillo, Sonora, México;5. Coordinación de Tecnología de Alimentos de Origen Vegetal. Centro de Investigación en Alimentación y Desarrollo, A. C. Carretera Gustavo Enrique Aztiazarán Rosas No. 42, 83304 Hermosillo, Sonora, México;6. Universidad Autónoma de Baja California, Facultad de Medicina de Mexicali, Lic. en Nutrición, Dr. Humberto Torres Sanginés S/N, Centro Cívico, Mexicali, Baja California, 21000 México;7. Conacyt-Centro de Investigación en Alimentación y Desarrollo A. C., Carretera Gustavo Enrique Astiazarán Rosas No. 46, Col. La Victoria, Hermosillo, 83304 Mexico |
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| Abstract: | This study aimed to determine the phenolic compounds profile, antioxidant potential and cytotoxicity of extracts and fractions of Caesalpinia palmeri. Methanolic extracts were generated from C. palmeri berries, stems and flowers. The latter was subjected to liquid-liquid partition, obtaining hexane, ethyl acetate and residues fractions. Results showed that the flower extract and ethyl acetate fraction had a larger concentration of phenolic compounds (148.9 and 307.9 mg GAE/g, respectively), being ellagic acid (6233.57 and 19550.08 μg/g, respectively), quercetin-3-β-glycoside (3023.85 and 8952.55 μg/g, respectively) and gallic acid (2212.98 and 8422.34 μg/g, respectively) the most abundant compounds. Flower extract and ethyl acetate fraction also presented the highest antioxidant capacity on all tested methods (DPPH, ABTS, ORAC and FRAP) and low cytotoxicity against ARPE-19 cells (IC50 >170 μg/mL). C. palmeri possessed high antioxidant potential, associated with the presence of phenolic compounds and low cytotoxicity, suggesting that they could represent an option to counter oxidative stress. |
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| Keywords: | Caesalpinia palmeri phenolic compounds antioxidants cytotoxicity |
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