Use of an antiarrhythmic drug against acute selenium toxicity |
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| Institution: | 1. Van Yüzüncü Yıl University, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Van, Turkey;2. Van Yüzüncü Yıl University, Faculty of Veterinary Medicine, Department of Internal Medicine, Van, Turkey;3. Hatay Mustafa Kemal University, Faculty of Veterinary Medicine, Pathology Department, Hatay, Turkey;4. Van Yüzüncü Yıl University, Faculty of Veterinary Medicine, Pathology Department, Van, Turkey;5. Van Yüzüncü Yıl University, Health Services Vocational School, Van, Turkey;1. Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, Jiangsu Collaborative Innovation Center for Atmospheric Environment & Equipment Technology, School of Environmental Science and Engineering, Nanjing University of Information Science & Technology, Nanjing 210044, Jiangsu, P. R. China;2. Institute of Chemical Materials, Chinese Academy of Engineering Physics, Mianyang 621999, Sichuan, P. R. China;1. Ioffe Institute, Russian Academy of Sciences, 194021 St. Petersburg, Russian Federation;2. Department of Chemical Science and Technology, Hosei University, 184-8584 Kajino, Koganei, Tokyo, Japan;3. Department of Chemistry, Graduate School of Science, Tohoku University, 980-8578 Miyagi, Sendai, Japan;4. Department of Physics, Ben-Gurion University of the Negev, P.O. Box 653, 8410501 Be’er Sheva, Israel;1. Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, London, UK;2. University College London Consortium for Mitochondrial Research, London, UK;1. Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Fishery College, Huazhong Agricultural University, Wuhan 430070, China;2. Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, 1 Wenhai Road, Qingdao 266237, China;1. Department of Bromatology, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097, Warsaw, Poland;2. Department of Biochemistry and Pharmacogenomics, Faculty of Pharmacy and Laboratory of Biochemistry and Clinical Chemistry at the Preclinical Research Center, Medical University of Warsaw, Banacha 1, 02-097, Warsaw, Poland;3. Department of Pathology and Veterinary Diagnostics, Warsaw University of Life Sciences, Nowoursynowska 159 c, 02-776, Warsaw, Poland |
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| Abstract: | ObjectiveSelenium is an essential trace element. But, selenium may have toxic effects in high doses. There are no proven antidotes or curative treatments for acut selenium toxicity. Treatment involves stopping the exposure and providing supportive care for symptoms. Therefore, it is necessary to find more effective substances in the treatment of selenium toxicity. The aim of this study was to increase the survival rate of animals by supporting the heart with amiodarone and to determine the effect of amiodarone on the pathological, hematological and biochemical parameters in acute selenium intoxication.Methods64 Wistar-Albino rats were divided into four groups. Group I was given only distilled water, Group II was given 18 mg/kg dose of amiodarone, Group III was given 18 mg/kg amiodarone and 10 mg/kg sodium selenite and Group IV was given sodium selenite 10 mg/kg (LD50 dose)orally.Results11 of the 16 animals in Group IV died within the first 48 h of drug administration. However, no deaths were observed in the rats in Group III. No hematological changes were observed. Biochemically, CK, CK-MB and LDH levels of Group IV were higher than the other groups on both the 2nd and 10th days. In Groups II and III, this serum level decreased, and vitamin B12 levels increased. In macroscopic inspections of the organs of Groups III and IV, slight paleness was detected. Histopathologically, degenerative changes in tissue were observed, especially in Group IV.ConclusionThis study shows that amiodarone application has a reducing effect on selenium toxicity. This was because amiodarone protected the heart by reducing CK and CK-MB levels and increased vitamin B12 levels, which play a role in the synthesis of S-adenosyl methionine that converts selenium into a nontoxic form. |
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| Keywords: | Selenium Amiodarone Acute toxicity Survival rate |
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