Low selenium levels are associated with decreased bone mineral densities |
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| Affiliation: | 1. Health Promotion Center, CHA Bundang Medical Center, CHA University School of Medicine, 335 Pangyo-ro, Bundang-gu, Gyeonggi-do, 13488, Republic of Korea;2. Yeojuasan Health Clinic, 10, Sejong-ro, Yeoju-si, Gyeonggi-do, 12622, Republic of Korea;3. Department of Orthopaedic Surgery, CHA Bundang Medical Center, CHA University School of Medicine, 335 Pangyo-ro, Bundang-gu, Gyeonggi-do, 13488, Republic of Korea;4. CHA Graduate School of Medicine, 120 Hyeryong-ro, Pocheon, 11160, Republic of Korea;1. Department of Environment and Health, Italian National Institute for Health, Viale Regina Elena 299, 00161 Rome, Italy;2. Department of Biomedical Sciences—Histology, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy;3. Department of Medical Surgical and Experimental Sciences, Ophthalmology Unit, University of Sassari, Viale San Pietro 43/C, 07100 Sassari, Italy;4. I.S.R.C.T.––International Society for Research on Cadmium Toxicity, Viale San Pietro 43/B, 07100 Sassari, Italy;1. L.B.P.O/Section Endocrinology, Faculty of Biological Sciences, USTHB, BP 32 El-Alia, Bab Ezzouar, 16 111 Algiers, Algeria;2. Departement of Biology, Faculty of Biological Sciences and Agricultural Sciences, UMMTO, 15 000 Tizi-Ouzou, Algeria;3. ETH Zurich, Zurich, Switzerland;4. Iodine Global Network, Ottawa, Ontario, Canada;5. Endocrinology Department, Public Hospital Etablishment IbnZiri, Bologhine, 16090 Algiers, Algeria;1. Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, Changsha, 410078, China;2. Center of Clinical Pharmacology, the Third Xiangya Hospital, Central South University, Changsha, 410013, China;3. Environmental Science and Engineering, College of Resource and Environment, Hunan Agricultural University, Changsha, 410128, China;4. Department of Occupational and Environmental Health, Huazhong University of Science and Technology, Wuhan, 430030, China;5. Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, 410078, China;6. Hunan Occupational Disease Prevention and Control Institute, Changsha, 410007, China;7. Public Health College, Kunming Medical University, Kunming, 650500, China;8. Center for Environment and Health in Water Source Area of South-to-North Water Diversion, Hubei University of Medicine, Shiyan, 442000, China;9. Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, China |
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| Abstract: | PurposeOsteoporosis has a high worldwide prevalence and detrimental consequences (e.g., increased fracture risk). The amount of bone mineral in bone tissue (i.e., bone mineral density [BMD]) is most widely used indicator of osteoporosis in clinical medicine. Selenium is an essential micronutrient for animals and humans. It is a cofactor for antioxidant enzyme reduction (e.g., glutathione peroxidase). It also enhances immune surveillance and modulates cell proliferation. Study findings on the associations between BMD and selenium levels are inadequate and contradictory. The purpose of this study was to examine the associations between hair selenium levels and lumbar spine and femur BMD values.MethodsUsing a cross-sectional study design, we assessed the associations between hair selenium levels and BMD values in 1,167 Korean adults who underwent a health check-up. Each subject was assigned to one of two groups based on BMD (normal group [T-score ≥ -1.0] or low BMD group [T-score < -1.0]). The associations between hair selenium levels and the risk for low BMD were estimated using multivariate logistic regression models.ResultsStudy participants with lower hair selenium levels were older and had higher phosphorous, alkaline phosphatase, and osteocalcin levels. They also had lower BMDs, corrected serum calcium levels, uric acid levels, and creatinine clearance. Participants with low BMDs had significantly lower hair selenium levels (P < 0.001). After adjusting for osteoporosis-related risk factors, the risk of a low BMD was significantly greater for the lower hair selenium quartile groups (P = 0.045).ConclusionIn conclusion, this study found that lower hair selenium levels were associated with low BMD values, independent of the other osteoporosis risk factors examined. Further prospective studies are warranted to determine the role of selenium in the development of osteoporosis. |
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| Keywords: | Selenium Hair Osteoporosis Osteopenia Bone mineral density |
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