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Multi-scale data-driven engineering for biosynthetic titer improvement
Affiliation:1. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China;2. MOE Key Laboratory of Advanced Control and Optimization for Chemical Processes, East China University of Science and Technology, Shanghai 200237, China;3. State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China;4. Key Biosensor Laboratory of Shandong Province, Biology Institute, QiluUniversity of Technology (Shandong Academy of Sciences), Jinan, 250013, China;5. Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China;6. Shandong Jincheng Bio-Pharmaceutical Co., Ltd., No. 117 Qixing River Road, Zibo 255130, Shandong, China;7. Shijiazhuang XingbaiBioengineering Co., Ltd, Shijiazhuang 050000, China;8. Inner Mongolia New VeyongBiochemical Co., Ltd, Dalad Banner 014300, China;9. Department of Biology and Biological Engineering, Chalmers University of Technology, Kemivägen 10, SE412 96 Gothenburg, Sweden;1. Department Microbial Natural Products, Actinobacteria Metabolic Engineering Group, Saarland University, Campus C2.3, 66123 Saarbrücken, Germany;2. Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infectious Research (HZI), Germany;3. i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal;4. IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal;1. Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 518055, Shenzhen, China;2. State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China;3. State Key Laboratory of Bioreactor Engineering, And School of Biotechnology, East China University of Science and Technology (ECUST), Shanghai, 200237, China;4. University of Chinese Academy of Sciences, Beijing 100049, China;1. Helmholtz Institute for Pharmaceutical Research, 66123 Saarbrücken, Germany;2. University of Saarland, Pharmaceutical Biotechnology, 66123 Saarbrücken, Germany;1. Pharmazeutische Biotechnologie, Universität des Saarlandes, Saarbrücken, Germany;2. Ecologie Microbienne UMR CNRS 5557, Université Lyon 1, Université de Lyon, Villeurbanne, France;3. Helmholtz-Institut für Pharmazeutische Forschung Saarland, Saarbrücken, Germany
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